BEGIN:VCALENDAR VERSION:2.0 PRODID:-//https://archive.synchrotron.org.au///NONSGML kigkonsult.se iCalcreator 2.10.15// METHOD:PUBLISH BEGIN:VEVENT UID:20260411T103917AEST-6331VkPTTK@https://archive.synchrotron.org.au/ DTSTAMP:20260411T003917Z DESCRIPTION:This talk will be presented by Dr Lisa M. Miller\nBiophysicist\ , Brookhaven National Laboratory\, NY \nAdjunct Assistant Professor\, Depa rtment of Biomedical Engineering\, Stony Brook University\nMember of Austr alian Synchrotron Science Advisory Committee\nWednesday 5 May 2010 @ 4.00p m\nLecture Theatre\n770 Blackburn Rd\, Clayton\nThe focus of our laborator y is on the study of the chemical makeup of tissue in disease using high-r esolution infrared and x-ray imaging at Brookhaven's National Synchrotron Light Source. We have two primary research areas: (1) examination of the c hemical composition of bone tissue in diseases such as osteoarthritis and osteoporosis\, and (2) correlation of metal ion content and protein struct ure in brain tissue in protein-folding diseases such as Alzheimer's diseas e and scrapie.\nIn many protein-folding diseases\, proteins that normally occur in the brain are found to misfold and aggregate\, causing neurologic al damage. These protein aggregates are often associated with high metal c ontent in the brain. For example\, high concentrations of zinc have been a ssociated with amyloid plaques in Alzheimer's disease. Using synchrotron x -ray and infrared imaging\, the metal ions and protein aggregates can be i maged and correlated. These findings will help to determine how the accumu lation of metal ions in the brain is associated with protein misfolding.\n Talk jointly hosted by: \nCSIRO\nMonash Centre for Synchrotron Science (MC SS)\nClayton Biomedical Imaging Laboratory\nAustralian Synchrotron\nARC Ce ntre for Coherent X-Ray Science\nFor further information\, contact Steve W ilkins \;on 03 \;9902 9802\n \; DTSTART:20100505T040000Z DTEND:20100505T050000Z LOCATION:Monash Centre for Synchrotron Science (770 Blackburn Road Clayton VIC) SUMMARY:Metal ions in Alzheimer's disease END:VEVENT END:VCALENDAR