Team

Expert beamline team, highly skilled in diffraction data collection and structure determination

Each member of the beamline team is highly competent in their area/s of expertise, resulting in a group that is multidisciplinary, yet dynamic and cohesive. The team maintains two state-of-the-art beamlines and dedicates substantial amounts of time to their continuous improvement and development while also continuing to excel internationally by regularly publishing in reputable, peer-review scientific journals.

Team skills and publications

Name: Dr rer. nat. Alan Riboldi-Tunnicliffe
Major skills: Drug design crystallography including receptors; beamline hardware development and robots.
Relevant publications (show/hide)

Name: Dr David Aragao
Major skills: Lipid cubic phase crystallisation and harvesting from sandwich plates; data collection on small crystals (10-80 microns), specialising in 'invisible crystals' such as membrane proteins grown by the lipid cubic phase methodology; data reduction of multiple 10-30 degree wedges to build a complete dataset.
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Name: Dr Jason Price
Major skills: Chemical crystallography from small molecules to large complexes.
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Name: Dr Santosh Panjikar
Major skills: Derivatisation of protein crystals; X-ray data collection; long wavelength phasing; UV Radiation Damage Induced Phasing (UV-RIP); automated structure determination.
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Name: Dr Tom Caradoc-Davies
Major skills: Protein crystallography and beamline instrumentation including controls and hardware.
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Authors	RJB Nibbs et al.	VF Prazeres et al.	RJ Payne et al.
Title	"Structure–Function Dissection of D6, an Atypical Scavenger Receptor"	"Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis andStreptomyces coelicolor Type II Dehydroquinase"	"Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases."
Publication	Methods Enzymol. (2009)460:245-61.	ChemMedChem. (2007)2:194-207.	ChemMedChem. (2007)2: 1010-1013

Authors	CL Gee et al.	CL Gee et al.
Title	"A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria"	"Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase"
Publication	Sci. Signal. (2012)5:ra7	J. Med. Chem. (2007)50:4845-4853.

Authors	S Stepanov et al.	DM Rosenbaum et al.	N Hoefer et al.
Title	"Fast fluorescence techniques for crystallography beamlines"	"Structure and function of an irreversible agonist-B2 adrenoceptor complex"	"Crystallizing Transmembrane Peptides in Lipidic Mesophases"
Publication	J. Appl. Cryst. (2011). 44, 772-8	Nature (2011)469:236–40	Biophys. J. (2010)99:L23-5<

Authors	B Bozic-Weber et al.	JR Price et al.
Title	"Sticky complexes: carboxylic acid-functionalized N-phenylpyridin-2-ylmethanimine ligands as anchoring domains for copper and ruthenium dye-sensitized solar cells"	"Factors influencing tetranuclear 2 x 2 grid vs dinuclear side-by-side structures for silver(I) complexes of pyridazine-based bis-bidentate ligands."
Publication	Dalton Trans. (2010)21:3585-94	Inorg Chem. (2008)17:10729-38

Authors	SJ Norwood et al.	NP Cowieson et al.	RHP Law et al.
Title	"Assembly and Solution Structure of the Core Retromer Protein Complex"	"United we stand: combining structural methods"	"The X-ray Crystal Structure of Full-Length Human Plasminogen"
Publication	Traffic. (2011). 12:56-71	Curr Opin Struct Biol. (2008)18:617-22.	Cell Rep (2012)1: 185-90

Authors	S Panjikar et al.	S Panjikar et al.
Title	"On the combination of molecular replacement and single-wavelength anomalous diffraction phasing for automated structure determination."	"Single isomorphous replacement phasing of selenomethionine-containing proteins using UV-induced radiation damage"
Publication	Acta Cryst. (2009)D65:1089-97	Acta Cryst. (2011)D67:32-44.

Team (MX)

Expert beamline team, highly skilled in diffraction data collection and structure determination

Team skills and publications